RESUMO
AIM: To study quality of life (QoL) in patients with celiac disease (CD) in the course of treatment with aglutenic diet (AD). MATERIAL AND METHODS: Modern algorithm of glutenic enteropathy diagnosis (enzyme immunoassay, histological examination of the biopsy of distal duodenum mucosa) was used in 650 patients with different gastrointestinal symptoms. QoL was assessed in the course of AD treatment of CD with application of universal standard questionnaire MOS SF-36. RESULTS: CD was diagnosed in 56 (8.6%) patients. Classic CD was diagnosed in 44 (78.6%) patients, atypical CD--in 12 (21.4%). Significant lowering of QoL characteristic psychological health" was observed in CD patients under 30 and over 50 and "physical health" in 30-50-year-old CD patients. Women had low points on "mental health" scale. After 3 AD months QoL worsened by all the scales, but after 12 months QoL significantly improved. CONCLUSION: QoL in patients with classic CD is associated with gender and age. First, AD deteriorates QoL, but 1-year diet therapy improves QoL.
Assuntos
Doença Celíaca/psicologia , Qualidade de Vida , Adolescente , Adulto , Doença Celíaca/dietoterapia , Dieta Livre de Glúten , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Inquéritos e Questionários , Adulto JovemAssuntos
Infecções por Helicobacter/tratamento farmacológico , Programas Nacionais de Saúde/organização & administração , Avaliação de Programas e Projetos de Saúde , Gastropatias/tratamento farmacológico , 2-Piridinilmetilsulfinilbenzimidazóis/administração & dosagem , 2-Piridinilmetilsulfinilbenzimidazóis/uso terapêutico , Antiulcerosos/administração & dosagem , Antiulcerosos/uso terapêutico , Cidades , Infecções por Helicobacter/complicações , Infecções por Helicobacter/epidemiologia , Infecções por Helicobacter/microbiologia , Helicobacter pylori/efeitos dos fármacos , Humanos , Programas Nacionais de Saúde/economia , Programas Nacionais de Saúde/normas , Rabeprazol , Federação Russa/epidemiologia , Gastropatias/epidemiologia , Gastropatias/etiologia , Gastropatias/microbiologia , Úlcera Gástrica/tratamento farmacológico , Úlcera Gástrica/epidemiologia , Úlcera Gástrica/etiologia , Úlcera Gástrica/microbiologiaRESUMO
The response of inflammation, bile secretion, lipid metabolism, LDL sensitivity to oxidation was studied in patients with bile duct dyskinesia (BDD), chronic cholecystitis (CC) and cholelithiasis (CL) before and after a course of therapy with galstena. The treatment improved general condition in 90% of the patients, dyspeptic symptoms relieved or stopped. Galstena relieved general or local inflammation, reduced mean levels of total cholesterol and LDL cholesterol, raised HDL cholesterol. In patients with BDD and cholelithiasis galstena did not change normal sensitivity of LDL to oxidation. A galstena course in BDD and CC patients significantly diminished bile lithogenicity and improved gall bladder contractility.
